| Title |
Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, August 2011
|
| DOI | 10.1007/s10549-011-1716-7 |
| Pubmed ID | |
| Authors |
Hongmei Zeng, Melinda L. Irwin, Lingeng Lu, Harvey Risch, Susan Mayne, Lina Mu, Qian Deng, Luca Scarampi, Marco Mitidieri, Dionyssios Katsaros, Herbert Yu |
| Abstract |
The study was conducted to determine the effect of physical activity on DNA methylation and to predict the consequence of this effect concerning gene expression and breast cancer survival. Blood samples, collected from 12 breast cancer patients who participated in a randomized clinical trial of exercise, were examined for exercise-related changes in DNA methylation using a methylation microarray. Tumor samples of 348 breast cancer patients were analyzed with qRT-PCR and qMSP to determine gene expression and methylation identified in the microarray analysis. Cox regression models were developed to predict survival outcomes in association with gene expression and methylation. After 6 months of moderate-intensity aerobic exercise, changes in DNA methylation (P < 5 × 10(-5)) in peripheral blood leukocytes were detected in 43 genes from a panel of 14 495. Based on the list, we analyzed gene expression in association with overall survival in breast tumors and found three genes whose methylation was reduced after exercise were favorably in association with overall survival, i.e., higher expression associated with better survival. Of the three genes, L3MBTL1 was a putative tumor suppressor gene with known function to repress chromatin for transcription, which is activated mainly in germline stem cells. Further analyses of tumor features among patients indicated that high expression of L3MBTL1 was associated with low grade and hormone receptor-positive tumors, as well as low risk of disease recurrence and breast cancer death. In conclusion, the study suggests that increasing physical activity after a breast cancer diagnosis may affect epigenetic regulation of tumor suppressor genes, which have favorable impacts on survival outcomes of breast cancer patients. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 13% |
| Australia | 1 | 13% |
| Unknown | 6 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
| Unknown | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 196 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | 1% |
| Uruguay | 2 | 1% |
| United States | 2 | 1% |
| Canada | 2 | 1% |
| Switzerland | 1 | <1% |
| Unknown | 187 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 19% |
| Researcher | 34 | 17% |
| Student > Master | 28 | 14% |
| Student > Bachelor | 21 | 11% |
| Professor > Associate Professor | 12 | 6% |
| Other | 36 | 18% |
| Unknown | 28 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 23% |
| Medicine and Dentistry | 39 | 20% |
| Biochemistry, Genetics and Molecular Biology | 33 | 17% |
| Nursing and Health Professions | 10 | 5% |
| Sports and Recreations | 10 | 5% |
| Other | 27 | 14% |
| Unknown | 32 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2018.
All research outputs
#1,606,988
of 22,649,029 outputs
Outputs from Breast Cancer Research and Treatment
#215
of 4,612 outputs
Outputs of similar age
#7,531
of 120,747 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#3
of 58 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,612 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,747 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.