| Title |
Seizure and Coma Following Kratom (Mitragynina speciosa Korth) Exposure
|
|---|---|
| Published in |
Journal of Medical Toxicology, April 2010
|
| DOI | 10.1007/s13181-010-0079-5 |
| Pubmed ID | |
| Authors |
Jamie L. Nelsen, Jeff Lapoint, Michael J. Hodgman, Kenneth M. Aldous |
| Abstract |
Reports of toxicity secondary to Kratom are rare and lack of diagnostic testing in human specimens has prevented confirmatory explanation of observed clinical effects. We present a novel case of serious human toxicity following Kratom use confirmed via quantitative analysis of urine by high performance liquid chromatography coupled to electrospray tandem mass spectrometry. A 64 year-old male was witnessed to have a seizure at home following kratom consumption. Upon arrival to the emergency department (ED), the patient was unresponsive. While in the ED, the patient sustained a second seizure. He was intubated to protect his airway. The remainder of his hospital course was uneventful. A urine specimen was collected shortly after admission and sent for analysis. The mitragynine concentration in the urine was 167 ± 15 ng/ml. We report a rare case of Kratom toxicity characterized by a seizure and coma confirmed by urinary analysis of mitragynine by high performance liquid chromatography coupled to electrospray tandem mass spectrometry. The proposed mechanism for this reaction is unclear but suggested mechanisms include adenosine binding or stimulation of adrenergic and/or serotonergic receptors similar to tramadol. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 30% |
| Unknown | 7 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 90% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 129 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 19 | 15% |
| Student > Bachelor | 15 | 12% |
| Student > Ph. D. Student | 12 | 9% |
| Student > Master | 9 | 7% |
| Researcher | 8 | 6% |
| Other | 24 | 18% |
| Unknown | 43 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 12% |
| Agricultural and Biological Sciences | 11 | 8% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Chemistry | 6 | 5% |
| Other | 20 | 15% |
| Unknown | 46 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2023.
All research outputs
#1,158,977
of 25,320,147 outputs
Outputs from Journal of Medical Toxicology
#72
of 720 outputs
Outputs of similar age
#3,538
of 102,270 outputs
Outputs of similar age from Journal of Medical Toxicology
#3
of 29 outputs
Altmetric has tracked 25,320,147 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 720 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,270 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.