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Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, August 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

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2 X users
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18 patents
peer_reviews
1 peer review site
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1 Wikipedia page

Citations

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646 Dimensions

Readers on

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350 Mendeley
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1 CiteULike
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Title
Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy
Published in
Proceedings of the National Academy of Sciences of the United States of America, August 2009
DOI 10.1073/pnas.0813327106
Pubmed ID
Authors

Cristina L. Zavaleta, Bryan R. Smith, Ian Walton, William Doering, Glenn Davis, Borzoyeh Shojaei, Michael J. Natan, Sanjiv S. Gambhir

Abstract

Raman spectroscopy is a newly developed, noninvasive preclinical imaging technique that offers picomolar sensitivity and multiplexing capabilities to the field of molecular imaging. In this study, we demonstrate the ability of Raman spectroscopy to separate the spectral fingerprints of up to 10 different types of surface enhanced Raman scattering (SERS) nanoparticles in a living mouse after s.c. injection. Based on these spectral results, we simultaneously injected the five most intense and spectrally unique SERS nanoparticles i.v. to image their natural accumulation in the liver. All five types of SERS nanoparticles were successfully identified and spectrally separated using our optimized noninvasive Raman imaging system. In addition, we were able to linearly correlate Raman signal with SERS concentration after injecting four spectrally unique SERS nanoparticles either s.c. (R(2) = 0.998) or i.v. (R(2) = 0.992). These results show great potential for multiplexed imaging in living subjects in cases in which several targeted SERS probes could offer better detection of multiple biomarkers associated with a specific disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 350 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Vietnam 1 <1%
United Kingdom 1 <1%
Korea, Republic of 1 <1%
Mexico 1 <1%
Canada 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 339 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 105 30%
Researcher 60 17%
Student > Master 38 11%
Student > Doctoral Student 19 5%
Student > Bachelor 18 5%
Other 56 16%
Unknown 54 15%
Readers by discipline Count As %
Chemistry 87 25%
Engineering 56 16%
Agricultural and Biological Sciences 35 10%
Materials Science 26 7%
Physics and Astronomy 23 7%
Other 57 16%
Unknown 66 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2023.
All research outputs
#2,385,506
of 24,654,416 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#27,821
of 101,572 outputs
Outputs of similar age
#8,425
of 117,495 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#167
of 722 outputs
Altmetric has tracked 24,654,416 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,572 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 117,495 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 722 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.