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X Demographics
Mendeley readers
| Title |
Heat Shock Protein 70 Reduces α‐Synuclein‐Induced Predegenerative Neuronal Dystrophy in the α‐Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease
|
|---|---|
| Published in |
CNS Neuroscience & Therapeutics, November 2013
|
| DOI | 10.1111/cns.12200 |
| Pubmed ID | |
| Authors |
Teresa C. Moloney, Rhona Hyland, Daniel O'Toole, Alexia Paucard, Deniz Kirik, Aideen O'Doherty, Adrienne M. Gorman, Eilís Dowd |
| Abstract |
It has become increasingly evident that the nigrostriatal degeneration associated with Parkinson's disease initiates at the level of the axonal terminals in the putamen, and this nigrostriatal terminal dystrophy is either caused or exacerbated by the presence of α-synuclein immunopositive neuronal inclusions. Therefore, strategies aimed at reducing α-synuclein-induced early neuronal dystrophy may slow or halt the progression to overt nigrostriatal neurodegeneration. Thus, this study sought to determine if adeno-associated virus (AAV) mediated overexpression of two molecular chaperone heat shock proteins, namely Hsp27 or Hsp70, in the AAV-α-synuclein viral gene transfer rat model of Parkinson's disease could prevent α-synuclein-induced early neuronal pathology. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 59 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 18% |
| Student > Ph. D. Student | 10 | 17% |
| Researcher | 8 | 13% |
| Student > Master | 6 | 10% |
| Student > Doctoral Student | 5 | 8% |
| Other | 12 | 20% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 20% |
| Biochemistry, Genetics and Molecular Biology | 11 | 18% |
| Agricultural and Biological Sciences | 7 | 12% |
| Medicine and Dentistry | 7 | 12% |
| Immunology and Microbiology | 2 | 3% |
| Other | 9 | 15% |
| Unknown | 12 | 20% |