| Title |
Epigenetic mechanisms in mammals
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2008
|
| DOI | 10.1007/s00018-008-8432-4 |
| Pubmed ID | |
| Authors |
J. K. Kim, M. Samaranayake, S. Pradhan |
| Abstract |
DNA and histone methylation are linked and subjected to mitotic inheritance in mammals. Yet how methylation is propagated and maintained between successive cell divisions is not fully understood. A series of enzyme families that can add methylation marks to cytosine nucleobases, and lysine and arginine amino acid residues has been discovered. Apart from methyltransferases, there are also histone modification enzymes and accessory proteins, which can facilitate and/or target epigenetic marks. Several lysine and arginine demethylases have been discovered recently, and the presence of an active DNA demethylase is speculated in mammalian cells. A mammalian methyl DNA binding protein MBD2 and de novo DNA methyltransferase DNMT3A and DNMT3B are shown experimentally to possess DNA demethylase activity. Thus, complex mammalian epigenetic mechanisms appear to be dynamic yet reversible along with a well-choreographed set of events that take place during mammalian development. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 684 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 1% |
| Spain | 3 | <1% |
| Chile | 2 | <1% |
| Italy | 2 | <1% |
| Brazil | 2 | <1% |
| United Kingdom | 2 | <1% |
| Austria | 1 | <1% |
| Sweden | 1 | <1% |
| India | 1 | <1% |
| Other | 9 | 1% |
| Unknown | 654 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 145 | 21% |
| Student > Bachelor | 97 | 14% |
| Researcher | 95 | 14% |
| Student > Master | 88 | 13% |
| Student > Doctoral Student | 40 | 6% |
| Other | 110 | 16% |
| Unknown | 109 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 225 | 33% |
| Biochemistry, Genetics and Molecular Biology | 158 | 23% |
| Medicine and Dentistry | 70 | 10% |
| Neuroscience | 19 | 3% |
| Chemistry | 17 | 2% |
| Other | 69 | 10% |
| Unknown | 126 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#6,469,703
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,363
of 4,151 outputs
Outputs of similar age
#29,217
of 94,620 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#19
of 44 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,620 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.