| Title |
Click Chemistry, A Powerful Tool for Pharmaceutical Sciences
|
|---|---|
| Published in |
Pharmaceutical Research, May 2008
|
| DOI | 10.1007/s11095-008-9616-1 |
| Pubmed ID | |
| Authors |
Christopher D. Hein, Xin-Ming Liu, Dong Wang |
| Abstract |
Click chemistry refers to a group of reactions that are fast, simple to use, easy to purify, versatile, regiospecific, and give high product yields. While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes has emerged as the frontrunner. It has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical sciences. In this manuscript, important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications. Bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered. Limitations of the reaction will also be discussed. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 17% |
| Sweden | 1 | 17% |
| United States | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 50% |
| Practitioners (doctors, other healthcare professionals) | 2 | 33% |
| Members of the public | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,206 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 6 | <1% |
| India | 5 | <1% |
| United States | 3 | <1% |
| Iran, Islamic Republic of | 2 | <1% |
| United Kingdom | 2 | <1% |
| Russia | 2 | <1% |
| Poland | 2 | <1% |
| Hong Kong | 1 | <1% |
| Canada | 1 | <1% |
| Other | 9 | <1% |
| Unknown | 1173 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 263 | 22% |
| Student > Bachelor | 207 | 17% |
| Student > Master | 184 | 15% |
| Researcher | 117 | 10% |
| Student > Doctoral Student | 49 | 4% |
| Other | 130 | 11% |
| Unknown | 256 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 485 | 40% |
| Biochemistry, Genetics and Molecular Biology | 129 | 11% |
| Agricultural and Biological Sciences | 79 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 53 | 4% |
| Engineering | 47 | 4% |
| Other | 137 | 11% |
| Unknown | 276 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#813,001
of 25,584,565 outputs
Outputs from Pharmaceutical Research
#14
of 3,004 outputs
Outputs of similar age
#1,639
of 98,771 outputs
Outputs of similar age from Pharmaceutical Research
#1
of 42 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,004 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,771 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.