Title |
α-Catenin cytomechanics – role in cadherin-dependent adhesion and mechanotransduction
|
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Published in |
Journal of Cell Science, February 2014
|
DOI | 10.1242/jcs.139014 |
Pubmed ID | |
Authors |
Adrienne K. Barry, Hamid Tabdili, Ismaeel Muhamed, Jun Wu, Nitesh Shashikanth, Guillermo A. Gomez, Alpha S. Yap, Cara J. Gottardi, Johan de Rooij, Ning Wang, Deborah E. Leckband |
Abstract |
The findings presented here demonstrate the role of α-catenin in cadherin-based adhesion and mechanotransduction in different mechanical contexts. Bead-twisting measurements in conjunction with imaging, and the use of different cell lines and α-catenin mutants reveal that the acute local mechanical manipulation of cadherin bonds triggers vinculin and actin recruitment to cadherin adhesions in an actin- and α-catenin-dependent manner. The modest effect of α-catenin on the two-dimensional binding affinities of cell surface cadherins further suggests that force-activated adhesion strengthening is due to enhanced cadherin-cytoskeletal interactions rather than to α-catenin-dependent affinity modulation. Complementary investigations of cadherin-based rigidity sensing also suggest that, although α-catenin alters traction force generation, it is not the sole regulator of cell contractility on compliant cadherin-coated substrata. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Germany | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
France | 1 | <1% |
Singapore | 1 | <1% |
Canada | 1 | <1% |
Unknown | 145 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 56 | 37% |
Researcher | 27 | 18% |
Student > Doctoral Student | 10 | 7% |
Student > Bachelor | 10 | 7% |
Student > Master | 9 | 6% |
Other | 19 | 13% |
Unknown | 20 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 53 | 35% |
Biochemistry, Genetics and Molecular Biology | 38 | 25% |
Engineering | 14 | 9% |
Physics and Astronomy | 8 | 5% |
Chemistry | 5 | 3% |
Other | 10 | 7% |
Unknown | 23 | 15% |