| Title |
Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, February 2014
|
| DOI | 10.1007/s00216-014-7668-0 |
| Pubmed ID | |
| Authors |
Ariane Wohlfarth, Adarsh S. Gandhi, Shaokun Pang, Mingshe Zhu, Karl B. Scheidweiler, Marilyn A. Huestis |
| Abstract |
PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are new synthetic cannabinoids with a quinoline substructure and the first marketed substances with an ester bond linkage. No human metabolism data are currently available, making it difficult to document PB-22 and 5F-PB-22 intake from urine analysis, and complicating assessment of the drugs' pharmacodynamic and toxicological properties. |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Switzerland | 1 | 1% |
| Unknown | 78 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 17% |
| Researcher | 13 | 16% |
| Student > Ph. D. Student | 13 | 16% |
| Student > Bachelor | 11 | 14% |
| Student > Postgraduate | 6 | 7% |
| Other | 12 | 15% |
| Unknown | 12 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 25 | 31% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 15% |
| Medicine and Dentistry | 7 | 9% |
| Agricultural and Biological Sciences | 7 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 9 | 11% |
| Unknown | 17 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2023.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Analytical & Bioanalytical Chemistry
#2,202
of 9,619 outputs
Outputs of similar age
#100,406
of 329,388 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#20
of 74 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,619 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,388 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.