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Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer

Overview of attention for article published in International Journal of Cell Biology, August 2013
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Title
Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer
Published in
International Journal of Cell Biology, August 2013
DOI 10.1155/2013/151839
Pubmed ID
Authors

Chiara Naro, Claudio Sette

Abstract

Alternative splicing (AS) is one of the key processes involved in the regulation of gene expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the joining of selected exons, thus ensuring the correct processing of the primary transcript into the mature mRNA. The combinatorial nature of AS allows a great expansion of the genome coding potential, as multiple splice-variants encoding for different proteins may arise from a single gene. Splicing is mediated by a large macromolecular complex, the spliceosome, whose activity needs a fine regulation exerted by cis-acting RNA sequence elements and trans-acting RNA binding proteins (RBP). The activity of both core spliceosomal components and accessory splicing factors is modulated by their reversible phosphorylation. The kinases and phosphatases involved in these posttranslational modifications significantly contribute to AS regulation and to its integration in the complex regulative network that controls gene expression in eukaryotic cells. Herein, we will review the major canonical and noncanonical splicing factor kinases and phosphatases, focusing on those whose activity has been implicated in the aberrant splicing events that characterize neoplastic transformation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 1%
United States 1 <1%
France 1 <1%
Unknown 159 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 26%
Researcher 27 17%
Student > Master 20 12%
Student > Doctoral Student 14 9%
Student > Bachelor 12 7%
Other 23 14%
Unknown 24 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 62 38%
Biochemistry, Genetics and Molecular Biology 50 31%
Immunology and Microbiology 4 2%
Chemistry 4 2%
Engineering 4 2%
Other 12 7%
Unknown 27 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2014.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from International Journal of Cell Biology
#99
of 145 outputs
Outputs of similar age
#160,845
of 212,174 outputs
Outputs of similar age from International Journal of Cell Biology
#7
of 8 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 145 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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