| Title |
Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms
|
|---|---|
| Published in |
Cell and Tissue Research, November 2009
|
| DOI | 10.1007/s00441-009-0892-9 |
| Pubmed ID | |
| Authors |
Samuel Schmidt, Peter Friedl |
| Abstract |
Adhesion and migration are integrated cell functions that build, maintain and remodel the multicellular organism. In migrating cells, integrins are the main transmembrane receptors that provide dynamic interactions between extracellular ligands and actin cytoskeleton and signalling machineries. In parallel to integrins, other adhesion systems mediate adhesion and cytoskeletal coupling to the extracellular matrix (ECM). These include multifunctional cell surface receptors (syndecans and CD44) and discoidin domain receptors, which together coordinate ligand binding with direct or indirect cytoskeletal coupling and intracellular signalling. We review the way that the different adhesion systems for ECM components impact cell migration in two- and three-dimensional migration models. We further discuss the hierarchy of these concurrent adhesion systems, their specific tasks in cell migration and their contribution to migration in three-dimensional multi-ligand tissue environments. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 309 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| United Kingdom | 4 | 1% |
| Germany | 2 | <1% |
| India | 2 | <1% |
| Italy | 1 | <1% |
| Sweden | 1 | <1% |
| United Arab Emirates | 1 | <1% |
| Netherlands | 1 | <1% |
| China | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 290 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 97 | 31% |
| Researcher | 50 | 16% |
| Student > Master | 32 | 10% |
| Student > Bachelor | 22 | 7% |
| Professor > Associate Professor | 22 | 7% |
| Other | 39 | 13% |
| Unknown | 47 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 109 | 35% |
| Biochemistry, Genetics and Molecular Biology | 38 | 12% |
| Engineering | 28 | 9% |
| Medicine and Dentistry | 23 | 7% |
| Immunology and Microbiology | 11 | 4% |
| Other | 50 | 16% |
| Unknown | 50 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2014.
All research outputs
#18,563,902
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#1,645
of 2,279 outputs
Outputs of similar age
#155,898
of 170,476 outputs
Outputs of similar age from Cell and Tissue Research
#11
of 11 outputs
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So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.