| Title |
The use of Trichuris suis and other helminth therapies to treat Crohn’s disease
|
|---|---|
| Published in |
Parasitology Research, January 2007
|
| DOI | 10.1007/s00436-006-0416-4 |
| Pubmed ID | |
| Authors |
Aditya Reddy, Bernard Fried |
| Abstract |
Infections with gastrointestinal (GI) nematodes are prevalent worldwide, despite the fact that anti-helminthic medications are regarded as safe, efficient, and widely available globally. In this review, we highlight the potential therapeutic benefits that may be realized through the clinical use of Trichuris suis and other helminths for Crohn's disease (CD). Long-lived helminthic parasites are remarkable in their ability to down-regulate host immunity, protecting themselves from elimination, and also minimize severe pathological host changes. This review summarizes what is known about the underlying mechanisms that may account for the observed patterns in humans treated with helminths for CD. The Th2 arm of the immune system is emphasized as a component of primary importance in the association between the host immune system and GI nematode infections. Although GI nematode infections in humans cause significant morbidity and mortality, the existence and nature of protective mechanisms these helminths may confer remain largely unclear. |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 7% |
| Denmark | 2 | 3% |
| Canada | 1 | 2% |
| Unknown | 52 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 15% |
| Researcher | 7 | 12% |
| Student > Bachelor | 7 | 12% |
| Student > Master | 6 | 10% |
| Professor | 5 | 8% |
| Other | 17 | 29% |
| Unknown | 8 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 31% |
| Medicine and Dentistry | 12 | 20% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Immunology and Microbiology | 3 | 5% |
| Unspecified | 2 | 3% |
| Other | 8 | 14% |
| Unknown | 11 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2022.
All research outputs
#3,389,508
of 23,419,482 outputs
Outputs from Parasitology Research
#168
of 3,834 outputs
Outputs of similar age
#13,096
of 159,776 outputs
Outputs of similar age from Parasitology Research
#2
of 15 outputs
Altmetric has tracked 23,419,482 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,834 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 159,776 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.