| Title |
Perspectives on the mesenchymal origin of metastatic cancer
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, September 2010
|
| DOI | 10.1007/s10555-010-9254-z |
| Pubmed ID | |
| Authors |
Leanne C. Huysentruyt, Thomas N. Seyfried |
| Abstract |
Emerging evidence suggests that many metastatic cancers arise from cells of the myeloid/macrophage lineage regardless of the primary tissue of origin. A myeloid origin of metastatic cancer stands apart from origins involving clonal evolution or epithelial-mesenchymal transitions. Evidence is reviewed demonstrating that numerous human cancers express multiple properties of macrophages including phagocytosis, fusogenicity, and gene/protein expression. It is unlikely that the macrophage properties expressed in metastatic cancers arise from sporadic random mutations in epithelial cells, but rather from damage to an already existing mesenchymal cell, e.g., a myeloid/macrophage-type cell. Such cells would naturally embody the capacity to express the multiple behaviors of metastatic cells. The view of metastasis as a myeloid/macrophage disease will impact future cancer research and anti-metastatic therapies. |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 66 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 28% |
| Researcher | 16 | 23% |
| Student > Bachelor | 6 | 9% |
| Professor | 5 | 7% |
| Professor > Associate Professor | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 33% |
| Biochemistry, Genetics and Molecular Biology | 14 | 20% |
| Medicine and Dentistry | 11 | 16% |
| Engineering | 3 | 4% |
| Mathematics | 1 | 1% |
| Other | 4 | 6% |
| Unknown | 13 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2013.
All research outputs
#7,442,740
of 22,753,345 outputs
Outputs from Cancer and Metastasis Reviews
#286
of 807 outputs
Outputs of similar age
#34,443
of 95,614 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#10
of 17 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 807 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.