Title |
The Neurodevelopmental Hypothesis of Schizophrenia Convergent Clues from Epidemiology and Neuropathology
|
---|---|
Published in |
Psychiatric clinics of North America, July 2012
|
DOI | 10.1016/j.psc.2012.06.002 |
Pubmed ID | |
Authors |
Michael Piper, Monica Beneyto, Thomas H.J. Burne, Darryl W. Eyles, David A. Lewis, John J. McGrath |
Abstract |
The neurodevelopmental hypothesis of schizophrenia suggests that the disruption of early brain development increases the risk of later developing schizophrenia. This hypothesis focuses attention on critical periods of early brain development. From an epidemiologic perspective, various prenatal and perinatal risk factors have been linked to schizophrenia, including exposures related to infection, nutrition, and obstetric complications. From a genetic perspective, candidate genes have also been linked to altered brain development. In recent decades evidence from neuropathology has provided support for the neurodevelopmental hypothesis. Animal models involving early life exposures have been linked to changes in these same brain systems, providing convergent evidence for this long-standing hypothesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Italy | 1 | <1% |
Colombia | 1 | <1% |
Mexico | 1 | <1% |
Canada | 1 | <1% |
Unknown | 148 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 30 | 19% |
Student > Ph. D. Student | 21 | 14% |
Student > Bachelor | 19 | 12% |
Researcher | 14 | 9% |
Student > Doctoral Student | 11 | 7% |
Other | 32 | 21% |
Unknown | 28 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 28% |
Agricultural and Biological Sciences | 23 | 15% |
Psychology | 22 | 14% |
Neuroscience | 16 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 3% |
Other | 11 | 7% |
Unknown | 35 | 23% |