You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Persistent organic pollutants distribution in lipoprotein fractions in relation to cardiovascular disease and cancer
|
|---|---|
| Published in |
Environment International, January 2014
|
| DOI | 10.1016/j.envint.2013.12.017 |
| Pubmed ID | |
| Authors |
Stefan A. Ljunggren, Ingela Helmfrid, Samira Salihovic, Bert van Bavel, Gun Wingren, Mats Lindahl, Helen Karlsson |
| Abstract |
Persistent organic pollutants (POPs) are lipophilic environmental toxins that have been associated with cardiovascular disease (CVD) and cancer. The aim of this study was to investigate the concentrations of POPs in human high and low/very low-density lipoproteins (HDL and LDL/VLDL) and the possible association with CVD and cancer occurrence in individuals living in a contaminated area. Lipoproteins from 28 individuals (7 healthy controls, 8 subjects with cancer, 13 subjects with CVD) were isolated and the fraction-specific concentration of 20 different POPs was analyzed by high resolution gas chromatography/high resolution mass spectrometry. The activity of Paraoxonase 1 (PON1), an anti-oxidant in HDL, was determined in plasma of these 28 subjects and additional 50 subjects from the same area excluding diseases other than cancer or CVD. Fourteen polychlorinated biphenyls (PCBs) and three organochlorine pesticides were detected, and especially highly chlorinated PCBs were enriched in lipoproteins. Significantly higher concentrations of POPs were found among individuals with CVD or cancer compared to controls. Principal component analyses showed that POP concentrations in HDL were more associated with CVD, while POP concentrations in LDL/VLDL were more associated with cancer. PON1 activity was negatively correlated to sumPCB and a co-variation between decreased arylesterase-activity, increased PCB concentrations and CVD was found. This study shows that POPs are present in lipoproteins and were more abundant in individuals with CVD or cancer compared to healthy controls. The results also indicate that PCB exposure is accompanied by reduced PON1 activity that could impair the HDL function to protect against oxidation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 2% |
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 89 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 17% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Master | 12 | 13% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 9 | 10% |
| Other | 14 | 15% |
| Unknown | 20 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 20 | 21% |
| Agricultural and Biological Sciences | 13 | 14% |
| Medicine and Dentistry | 7 | 7% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Nursing and Health Professions | 6 | 6% |
| Other | 22 | 23% |
| Unknown | 20 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2017.
All research outputs
#8,261,756
of 25,373,627 outputs
Outputs from Environment International
#2,765
of 5,185 outputs
Outputs of similar age
#93,187
of 321,549 outputs
Outputs of similar age from Environment International
#26
of 45 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 5,185 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.8. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,549 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.