Title |
Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women
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Published in |
Gynecologic Oncology, March 2014
|
DOI | 10.1016/j.ygyno.2014.03.566 |
Pubmed ID | |
Authors |
Rebekah E. McWhirter, Russell J. Thomson, James R. Marthick, Alice R. Rumbold, Matthew A. Brown, Debbie Taylor-Thomson, Elaine L. Maypilama, John R. Condon, Joanne L. Dickinson |
Abstract |
A cluster of vulvar cancer exists in young Aboriginal women living in remote communities in Arnhem Land, Australia. A genetic case-control study was undertaken involving 30 cases of invasive vulvar cancer and its precursor lesion, high-grade vulvar intraepithelial neoplasia (VIN), and 61 controls, matched for age and community of residence. It was hypothesized that this small, isolated population may exhibit increased autozygosity, implicating recessive effects as a possible mechanism for increased susceptibility to vulvar cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 16% |
Student > Ph. D. Student | 7 | 16% |
Researcher | 6 | 14% |
Student > Bachelor | 5 | 11% |
Other | 2 | 5% |
Other | 6 | 14% |
Unknown | 11 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 20% |
Social Sciences | 6 | 14% |
Agricultural and Biological Sciences | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Environmental Science | 2 | 5% |
Other | 6 | 14% |
Unknown | 12 | 27% |