Title |
The silent and apparent neurological injury in transcatheter aortic valve implantation study (SANITY): concept, design and rationale
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Published in |
BMC Cardiovascular Disorders, April 2014
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DOI | 10.1186/1471-2261-14-45 |
Pubmed ID | |
Authors |
Jonathon P Fanning, Allan J Wesley, David G Platts, Darren L Walters, Eamonn M Eeles, Michael Seco, Oystein Tronstad, Wendy Strugnell, Adrian G Barnett, Andrew J Clarke, Judith Bellapart, Michael P Vallely, Peter J Tesar, John F Fraser |
Abstract |
The incidence of clinically apparent stroke in transcatheter aortic valve implantation (TAVI) exceeds that of any other procedure performed by interventional cardiologists and, in the index admission, occurs more than twice as frequently with TAVI than with surgical aortic valve replacement (SAVR). However, this represents only a small component of the vast burden of neurological injury that occurs during TAVI, with recent evidence suggesting that many strokes are clinically silent or only subtly apparent. Additionally, insult may manifest as slight neurocognitive dysfunction rather than overt neurological deficits. Characterisation of the incidence and underlying aetiology of these neurological events may lead to identification of currently unrecognised neuroprotective strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
United Kingdom | 2 | 25% |
India | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 75% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Italy | 1 | 1% |
Belgium | 1 | 1% |
Australia | 1 | 1% |
Unknown | 63 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 15% |
Student > Master | 9 | 13% |
Student > Doctoral Student | 6 | 9% |
Student > Bachelor | 6 | 9% |
Student > Ph. D. Student | 6 | 9% |
Other | 18 | 27% |
Unknown | 12 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 55% |
Psychology | 4 | 6% |
Neuroscience | 3 | 4% |
Engineering | 3 | 4% |
Nursing and Health Professions | 2 | 3% |
Other | 3 | 4% |
Unknown | 15 | 22% |