| Title |
Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells
|
|---|---|
| Published in |
Archives of Pharmacal Research, October 2008
|
| DOI | 10.1007/s12272-001-2110-5 |
| Pubmed ID | |
| Authors |
Hyo-Hyun Park, Soyoung Lee, Hee-Young Son, Seung-Bin Park, Mi-Sun Kim, Eun-Ju Choi, Thoudam S. K. Singh, Jeoung-Hee Ha, Maan-Gee Lee, Jung-Eun Kim, Myung Chul Hyun, Taeg Kyu Kwon, Yeo Hyang Kim, Sang-Hyun Kim |
| Abstract |
Mast cells participate in allergy and inflammation by secreting inflammatory mediators such as histamine and proinflammatory cytokines. Flavonoids are naturally occurring molecules with antioxidant, cytoprotective, and antiinflammatory actions. However, effect of flavonoids on the release of histamine and proinflammatory mediator, and their comparative mechanism of action in mast cells were not well defined. Here, we compared the effect of six flavonoids (astragalin, fisetin, kaempferol, myricetin, quercetin, and rutin) on the mast cell-mediated allergic inflammation. Fisetin, kaempferol, myricetin, quercetin, and rutin inhibited IgE or phorbol-12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-mediated histamine release in RBL-2H3 cells. These five flavonoids also inhibited elevation of intracellular calcium. Gene expressions and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and IL-8 were assessed in PMACI-stimulated human mast cells (HMC-1). Fisetin, quercetin, and rutin decreased gene expression and production of all the proinflammatory cytokines after PMACI stimulation. Myricetin attenuated TNF-alpha and IL-6 but not IL-1beta and IL-8. Fisetin, myricetin, and rutin suppressed activation of NF-kappaB indicated by inhibition of nuclear translocation of NF-kappaB, NF-kappaB/DNA binding, and NF-kappaB-dependent gene reporter assay. The pharmacological actions of these flavonoids suggest their potential activity for treatment of allergic inflammatory diseases through the down-regulation of mast cell activation. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 165 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 26 | 16% |
| Student > Master | 25 | 15% |
| Researcher | 18 | 11% |
| Student > Ph. D. Student | 16 | 10% |
| Other | 10 | 6% |
| Other | 28 | 17% |
| Unknown | 42 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 17% |
| Medicine and Dentistry | 23 | 14% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 9% |
| Nursing and Health Professions | 9 | 5% |
| Other | 28 | 17% |
| Unknown | 45 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2023.
All research outputs
#948,121
of 23,577,654 outputs
Outputs from Archives of Pharmacal Research
#5
of 1,316 outputs
Outputs of similar age
#2,016
of 92,860 outputs
Outputs of similar age from Archives of Pharmacal Research
#1
of 8 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,316 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 99% of its peers.
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