Title |
Dendritic Cells and Toll-Like Receptors 2 and 4 in the Ileum of Crohn's Disease Patients
|
---|---|
Published in |
Digestive Diseases and Sciences, December 2007
|
DOI | 10.1007/s10620-007-0105-x |
Pubmed ID | |
Authors |
Manuel A. Silva, Rodrigo Quera, Jorge Valenzuela, Sa’ad Y. Salim, Johan D. Söderholm, Mary H. Perdue |
Abstract |
We investigated myeloid-dendritic cell (DC) marker and Toll-like receptor (TLR)-2 and 4 distributions in ileal samples from Crohn's disease (CD) patients (n = 14) and controls (n = 13). In controls, no TLR-2+ cells were observed, and higher numbers of TLR-4+ and DC-SIGN+ cells (P < 0.01) were detected in ileal samples when compared versus colonic tissues. In non-inflamed CD ileum, TLR-4+ and DC-SGN+ cells were depleted from superficial areas of the villus, and a significant CD1a+ cell infiltration (P < 0.01) was observed when compared to ileal controls and non-inflamed colonic CD samples. In inflamed CD ileum, DC-SIGN+, CD1a+, TLR-4+and few TLR-4+DC-SIGN+ cells were detected as well as CD83 depletion. No correlation between TLR-2 and DC markers was detected in CD samples. A unique distribution of myeloid-DC markers characterized the CD ileum. Also, the presence of significant amounts of ileal CD1a+ cells may provide a relevant DC-mediated mechanism for antigen recognition in the pathogenesis of CD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 22% |
Student > Postgraduate | 2 | 22% |
Student > Ph. D. Student | 1 | 11% |
Unspecified | 1 | 11% |
Professor > Associate Professor | 1 | 11% |
Other | 1 | 11% |
Unknown | 1 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 33% |
Agricultural and Biological Sciences | 2 | 22% |
Immunology and Microbiology | 2 | 22% |
Unspecified | 1 | 11% |
Engineering | 1 | 11% |
Other | 0 | 0% |