| Title |
Update on psoriasis immunopathogenesis and targeted immunotherapy
|
|---|---|
| Published in |
Seminars in Immunopathology, November 2015
|
| DOI | 10.1007/s00281-015-0539-8 |
| Pubmed ID | |
| Authors |
Satveer K. Mahil, Francesca Capon, Jonathan N. Barker |
| Abstract |
Over recent years, significant progress has been made in characterisation of the underlying pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with major systemic co-morbidity and reduced life expectancy. Basic science discoveries have informed the design of novel therapeutic approaches, many of which are now under evaluation in late-stage clinical trials. Here we describe the complex interplay between immune cell types and cytokine networks that acts within self-perpetuating feedback loops to drive cutaneous inflammation in psoriasis. Genetic studies have been pivotal in the construction of the disease model and more recently have uncovered a distinct aetiology for rare, pustular variants of psoriasis. The translation of mechanistic insights into potential advancements in clinical care will also be described, including several treatments that target the interleukin-23 (IL-23)/T17 immune axis. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 4 | 80% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 274 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 274 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 37 | 14% |
| Student > Ph. D. Student | 31 | 11% |
| Student > Bachelor | 31 | 11% |
| Other | 24 | 9% |
| Researcher | 20 | 7% |
| Other | 39 | 14% |
| Unknown | 92 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 87 | 32% |
| Pharmacology, Toxicology and Pharmaceutical Science | 21 | 8% |
| Agricultural and Biological Sciences | 16 | 6% |
| Biochemistry, Genetics and Molecular Biology | 15 | 5% |
| Immunology and Microbiology | 13 | 5% |
| Other | 29 | 11% |
| Unknown | 93 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2024.
All research outputs
#635,027
of 25,389,116 outputs
Outputs from Seminars in Immunopathology
#15
of 672 outputs
Outputs of similar age
#8,579
of 267,424 outputs
Outputs of similar age from Seminars in Immunopathology
#1
of 16 outputs
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So far Altmetric has tracked 672 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.