| Title |
Th9 cells in the pathogenesis of EAE and multiple sclerosis
|
|---|---|
| Published in |
Seminars in Immunopathology, November 2016
|
| DOI | 10.1007/s00281-016-0604-y |
| Pubmed ID | |
| Authors |
Wassim Elyaman, Samia J. Khoury |
| Abstract |
Interleukin (IL)-9 producing CD4(+) T helper cells (Th9) are the newest addition to the T helper cell subsets. IL-9 binds to a heterodimeric receptor consisting of the IL-9 receptor (IL-9R) and a common γ chain also presents in IL-2, IL-4, IL-7, and IL-15 receptor complexes. In addition to Th9 cells, Th17 cells secrete smaller amounts of IL-9. Many functional and regulatory roles associated with Th9 cells are currently not fully understood. IL-9 is a pleiotropic cytokine that affects the activity of multiple cell types in the immune compartment as well as in the central nervous system (CNS). Initially implicated in type 2 inflammation, IL-9 has been recently shown to be a key player in regulating autoimmune responses in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Here, we review the current understanding of the role of Th9/IL-9 signaling in EAE and MS. We summarize the source and regulation of Th9 cells in vivo, the influence of IL-9 signaling on peripheral and CNS-resident cells in EAE, and the association between IL-9 and MS disease activity. |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 69 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 16% |
| Researcher | 9 | 13% |
| Student > Master | 7 | 10% |
| Student > Doctoral Student | 7 | 10% |
| Student > Bachelor | 7 | 10% |
| Other | 11 | 16% |
| Unknown | 18 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 14% |
| Immunology and Microbiology | 9 | 13% |
| Agricultural and Biological Sciences | 9 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Neuroscience | 5 | 7% |
| Other | 10 | 14% |
| Unknown | 21 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#7,535,755
of 22,992,311 outputs
Outputs from Seminars in Immunopathology
#233
of 552 outputs
Outputs of similar age
#112,474
of 308,028 outputs
Outputs of similar age from Seminars in Immunopathology
#7
of 13 outputs
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So far Altmetric has tracked 552 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.