| Title |
The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis
|
|---|---|
| Published in |
European Journal of Epidemiology, April 2014
|
| DOI | 10.1007/s10654-014-9895-2 |
| Pubmed ID | |
| Authors |
Gundula Behrens, Carmen Jochem, Marlen Keimling, Cristian Ricci, Daniela Schmid, Michael Fred Leitzmann |
| Abstract |
Physical activity may decrease gastroesophageal cancer risk through a reduction of oxidative stress and decreased chronic inflammation, yet few epidemiologic studies have been able to report a clear inverse association between physical activity and gastroesophageal cancer. Because no meta-analysis has investigated the relation of physical activity to gastroesophageal cancer, we conducted a comprehensive systematic review and meta-analysis according to the PRISMA guidelines based on 24 studies with a total of 15,745 cases. When we compared high versus low physical activity levels and summarized associations according to anatomic site and tumor histology, risk reductions were evident for esophageal adenocarcinoma [relative risk (RR) = 0.79, 95% confidence interval (CI) = 0.66-0.94], gastric cardia adenocarcinoma (RR = 0.83, 95% CI = 0.69-0.99) and gastric non-cardia adenocarcinoma (RR = 0.72, 95% CI = 0.62-0.84). The risk reduction for esophageal squamous cell carcinoma (RR = 0.94, 95% CI = 0.41-2.16) became statistically significant (RR = 0.66, 95% CI = 0.46-0.96) after excluding an influential study. The test for heterogeneity by gastroesophageal cancer subtype was statistically non-significant (p-difference = 0.71). The RR of total gastroesophageal cancer for high versus low physical activity was 0.82 (95% CI = 0.74-0.90). A dose-response analysis of frequency of physical activity and total gastroesophageal cancer risk revealed that the greatest risk reduction was achieved among those engaging in moderate to vigorous physical activity five times per week (RR = 0.67, 95% CI = 0.58-0.79). Our results provide support for an inverse relation of physical activity, in particular exercise frequency, to gastroesophageal cancer risk. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 20% |
| United Kingdom | 1 | 20% |
| Spain | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Lebanon | 1 | <1% |
| Unknown | 122 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 18% |
| Researcher | 20 | 16% |
| Student > Bachelor | 18 | 14% |
| Student > Master | 15 | 12% |
| Other | 7 | 6% |
| Other | 26 | 20% |
| Unknown | 18 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 35% |
| Sports and Recreations | 13 | 10% |
| Nursing and Health Professions | 12 | 9% |
| Agricultural and Biological Sciences | 8 | 6% |
| Biochemistry, Genetics and Molecular Biology | 5 | 4% |
| Other | 14 | 11% |
| Unknown | 30 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2023.
All research outputs
#911,938
of 24,375,780 outputs
Outputs from European Journal of Epidemiology
#135
of 1,753 outputs
Outputs of similar age
#9,066
of 230,592 outputs
Outputs of similar age from European Journal of Epidemiology
#3
of 23 outputs
Altmetric has tracked 24,375,780 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,753 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.1. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.