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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
|
|---|---|
| Published in |
Nature Genetics, April 2014
|
| DOI | 10.1038/ng.2938 |
| Pubmed ID | |
| Abstract |
Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGGs (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing. We identified recurrent somatic mutations in ACVR1 exclusively in DIPGs (32%), in addition to previously reported frequent somatic mutations in histone H3 genes, TP53 and ATRX, in both DIPGs and NBS-HGGs. Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40% of NBS-HGGs in infants. Mutations targeting receptor tyrosine kinase-RAS-PI3K signaling, histone modification or chromatin remodeling, and cell cycle regulation were found in 68%, 73% and 59% of pediatric HGGs, respectively, including in DIPGs and NBS-HGGs. This comprehensive analysis provides insights into the unique and shared pathways driving pediatric HGG within and outside the brainstem. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| United Kingdom | 1 | 13% |
| France | 1 | 13% |
| Belgium | 1 | 13% |
| Australia | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Scientists | 2 | 25% |
| Science communicators (journalists, bloggers, editors) | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 626 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | <1% |
| Germany | 2 | <1% |
| Netherlands | 2 | <1% |
| France | 2 | <1% |
| Spain | 2 | <1% |
| Japan | 2 | <1% |
| Sweden | 1 | <1% |
| Czechia | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 604 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 122 | 19% |
| Researcher | 121 | 19% |
| Student > Bachelor | 56 | 9% |
| Other | 47 | 8% |
| Student > Master | 46 | 7% |
| Other | 110 | 18% |
| Unknown | 124 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 149 | 24% |
| Biochemistry, Genetics and Molecular Biology | 141 | 23% |
| Agricultural and Biological Sciences | 102 | 16% |
| Neuroscience | 29 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 3% |
| Other | 42 | 7% |
| Unknown | 146 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 393. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2022.
All research outputs
#78,594
of 25,837,817 outputs
Outputs from Nature Genetics
#113
of 7,639 outputs
Outputs of similar age
#555
of 242,701 outputs
Outputs of similar age from Nature Genetics
#3
of 71 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,701 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.