| Title |
The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice
|
|---|---|
| Published in |
BMC Musculoskeletal Disorders, August 2011
|
| DOI | 10.1186/1471-2474-12-185 |
| Pubmed ID | |
| Authors |
Annabelle Z Caron, Sonia Haroun, Élisabeth Leblanc, Frédéric Trensz, Chantal Guindi, Aziz Amrani, Guillaume Grenier |
| Abstract |
Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction. This debilitating condition is associated with a marked activation of NFκB activity. The ubiquitin-proteasome pathway degrades the NFκB inhibitor IκBα, enabling NFκB to translocate to the nucleus and bind to the target genes that promote muscle atrophy. Although several studies showed that proteasome inhibitors are efficient to reduce atrophy, no studies have demonstrated the ability of these inhibitors to preserve muscle function under catabolic condition. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 82 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 21% |
| Researcher | 15 | 18% |
| Student > Master | 8 | 10% |
| Student > Bachelor | 8 | 10% |
| Professor > Associate Professor | 6 | 7% |
| Other | 13 | 15% |
| Unknown | 16 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 29% |
| Biochemistry, Genetics and Molecular Biology | 19 | 23% |
| Medicine and Dentistry | 13 | 15% |
| Sports and Recreations | 3 | 4% |
| Neuroscience | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 18 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2011.
All research outputs
#15,156,937
of 23,312,088 outputs
Outputs from BMC Musculoskeletal Disorders
#2,355
of 4,132 outputs
Outputs of similar age
#84,530
of 121,568 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#36
of 49 outputs
Altmetric has tracked 23,312,088 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,132 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,568 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.