Title |
Functional goal achievement in post-stroke spasticity patients: the BOTOX® Economic Spasticity Trial (BEST).
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Published in |
Journal of Rehabilitation Medicine, January 2014
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DOI | 10.2340/16501977-1817 |
Pubmed ID | |
Authors |
Anthony B Ward, Jörg Wissel, Jörgen Borg, Per Ertzgaard, Christoph Herrmann, Jai Kulkarni, Kristina Lindgren, Iris Reuter, Mohamed Sakel, Patrik Säterö, Satyendra Sharma, Theodore Wein, Nicola Wright, Antony Fulford-Smith |
Abstract |
Objective: Evaluate changes in active and passive function with onabotulinumtoxinA + standard of care within goal-oriented rehabilitation programmes in adults with focal post-stroke spasticity. Methods: Prospective, 24-week double-blind study with an open-label extension. Subjects were randomized to onabotulinumtoxinA + standard of care or placebo + standard of care, at baseline and at 12 weeks, if judged appropriate, with follow-up to 52 weeks. The primary endpoint was the number of patients achieving their principal active functional goal at 24 weeks (or 10 weeks after an optional second injection). Secondary endpoints included achievement of a different active or a passive goal at this timepoint. Results: The intent-to-treat population comprised 273 patients. The proportion of patients achieving their principal active functional goal and secondary active functional goal with onabotulinumtoxinA + standard of care was not statistically different from placebo + standard of care. Significantly more patients achieved their secondary passive goal with onabotulinumtoxinA + standard of care (60.0%) vs. placebo + standard of care (38.6%) (odds ratio, 2.46; 95% confidence interval, 1.18-5.14) as well as higher Goal Attainment Scaling levels for upper limb and ankle flexor subgroups. Conclusions: Addition of onabotulinumtoxinA to standard of care as part of goal-oriented rehabilitation in post-stroke spasticity patients significantly increased passive goal achievement and was associated with higher levels of active function. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | <1% |
Italy | 1 | <1% |
Canada | 1 | <1% |
Unknown | 117 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 16 | 13% |
Researcher | 15 | 13% |
Other | 13 | 11% |
Student > Bachelor | 12 | 10% |
Student > Ph. D. Student | 7 | 6% |
Other | 26 | 22% |
Unknown | 31 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 26 | 22% |
Nursing and Health Professions | 17 | 14% |
Neuroscience | 15 | 13% |
Agricultural and Biological Sciences | 7 | 6% |
Psychology | 3 | 3% |
Other | 13 | 11% |
Unknown | 39 | 33% |