| Title |
Epigenetic Enhancement of Brain-Derived Neurotrophic Factor Signaling Pathway Improves Cognitive Impairments Induced by Isoflurane Exposure in Aged Rats
|
|---|---|
| Published in |
Molecular Neurobiology, February 2014
|
| DOI | 10.1007/s12035-014-8659-z |
| Pubmed ID | |
| Authors |
MuHuo Ji, Lin Dong, Min Jia, WenXue Liu, MingQiang Zhang, LinSha Ju, JiaoJiao Yang, Zhongcong Xie, JianJun Yang |
| Abstract |
Isoflurane-induced cognitive impairments are well documented in animal models; yet, the molecular mechanisms remain largely to be determined. In the present study, 22-month-old male Sprague-Dawley rats received 2 h of 1.5 % isoflurane or 100 % oxygen daily for 3 consecutive days. For the intervention study, the rats were intraperitoneally injected with 1.2 g/kg sodium butyrate 2 h before isoflurane exposure. Our data showed that repeated isoflurane exposure significantly decreased the freezing time to context and the freezing time to tone in the fear conditioning test, which was associated with upregulated histone deacetylase 2, reduced histone acetylation, and increased inflammation and apoptosis in the hippocampus, and impairments of brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) and the downstream signaling pathway phospho-calmodulin-dependent protein kinase and phospho-cAMP response element-binding protein. These results suggest that isoflurane-induced cognitive impairments are associated with the declines in chromatin histone acetylation and the resulting downregulation of BDNF-TrkB signaling pathway. Moreover, the cognitive impairments and the signaling deficits can be rescued by histone deacetylase inhibitor sodium butyrate. Therefore, epigenetic enhancement of BDNF-TrkB signaling may be a promising strategy for reversing isoflurane-induced cognitive impairments. |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 41 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 24% |
| Student > Bachelor | 7 | 17% |
| Student > Master | 5 | 12% |
| Researcher | 4 | 10% |
| Professor | 3 | 7% |
| Other | 8 | 19% |
| Unknown | 5 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 19% |
| Medicine and Dentistry | 8 | 19% |
| Neuroscience | 8 | 19% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Unspecified | 2 | 5% |
| Other | 5 | 12% |
| Unknown | 8 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2014.
All research outputs
#20,228,193
of 22,753,345 outputs
Outputs from Molecular Neurobiology
#2,776
of 3,434 outputs
Outputs of similar age
#193,070
of 224,445 outputs
Outputs of similar age from Molecular Neurobiology
#20
of 26 outputs
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