| Title |
De novo synthesize of bile acids in pulmonary arterial hypertension lung
|
|---|---|
| Published in |
Metabolomics, April 2014
|
| DOI | 10.1007/s11306-014-0653-y |
| Pubmed ID | |
| Authors |
Yidan D. Zhao, Hana Z. H. Yun, Jenny Peng, Li Yin, Lei Chu, Licun Wu, Ryan Michalek, Mingyao Liu, Shaf Keshavjee, Thomas Waddell, John Granton, Marc de Perrot |
| Abstract |
Although multiple, complex molecular studies have been done for understanding the development and progression of pulmonary hypertension (PAH), little is known about the metabolic heterogeneity of PAH. Using a combination of high-throughput liquid-and-gas-chromatography-based mass spectrometry, we found bile acid metabolites, which are normally product derivatives of the liver and gallbladder, were highly increased in the PAH lung. Microarray showed that the gene encoding cytochrome P450 7B1 (CYP7B1), an isozyme for bile acid synthesis, was highly expressed in the PAH lung compared with the control. CYP7B1 protein was found to be primarily localized on pulmonary vascular endothelial cells suggesting de novo bile acid synthesis may be involved in the development of PAH. Here, by profiling the metabolomic heterogeneity of the PAH lung, we reveal a newly discovered pathogenesis mechanism of PAH. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 25% |
| Student > Ph. D. Student | 6 | 17% |
| Professor | 5 | 14% |
| Student > Doctoral Student | 3 | 8% |
| Other | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 10 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 22% |
| Medicine and Dentistry | 6 | 17% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 14 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2014.
All research outputs
#13,914,121
of 22,753,345 outputs
Outputs from Metabolomics
#715
of 1,292 outputs
Outputs of similar age
#117,409
of 226,967 outputs
Outputs of similar age from Metabolomics
#6
of 23 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,292 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.