Title |
The miRNAome of the postpartum dairy cow liver in negative energy balance
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Published in |
BMC Genomics, April 2014
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DOI | 10.1186/1471-2164-15-279 |
Pubmed ID | |
Authors |
Attia Fatima, David J Lynn, Padraic O’Boyle, Cathal Seoighe, Dermot Morris |
Abstract |
Negative energy balance (NEB) is an altered metabolic state in high yielding cows that occurs during the first few weeks postpartum when energy demands for lactation and maintenance exceed the energy supply from dietary intake. NEB can, in turn, lead to metabolic disorders and to reduced fertility. Alterations in the expression of more than 700 hepatic genes have previously been reported in a study of NEB in postpartum dairy cows. miRNAs (microRNA) are known to mediate many alterations in gene expression post transcriptionally. To study the hepatic miRNA content of postpartum dairy cows, including their overall abundance and differential expression, in mild NEB (MNEB) and severe NEB (SNEB), short read RNA sequencing was carried out. To identify putative targets of differentially expressed miRNAs among differentially expressed hepatic genes reported previously in dairy cows in SNEB computational target identification was employed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 23% |
Student > Master | 5 | 14% |
Student > Ph. D. Student | 5 | 14% |
Student > Doctoral Student | 3 | 9% |
Lecturer | 2 | 6% |
Other | 5 | 14% |
Unknown | 7 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 51% |
Veterinary Science and Veterinary Medicine | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Medicine and Dentistry | 2 | 6% |
Mathematics | 1 | 3% |
Other | 2 | 6% |
Unknown | 6 | 17% |