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Mendeley readers
Attention Score in Context
| Title |
A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans
|
|---|---|
| Published in |
Cell, November 2004
|
| DOI | 10.1016/j.cell.2004.11.022 |
| Pubmed ID | |
| Authors |
Gareth L. Bond, Wenwei Hu, Elisabeth E. Bond, Harlan Robins, Stuart G. Lutzker, Nicoleta C. Arva, Jill Bargonetti, Frank Bartel, Helge Taubert, Peter Wuerl, Kenan Onel, Linwah Yip, Shih-Jen Hwang, Louise C. Strong, Guillermina Lozano, Arnold J. Levine |
| Abstract |
The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore reasonable to assume that naturally occurring polymorphic genetic variants in the p53 stress response pathway might determine an individual's susceptibility to cancer. A central node in the p53 pathway is the MDM2 protein, a direct negative regulator of p53. In this report, a single nucleotide polymorphism (SNP309) is found in the MDM2 promoter and is shown to increase the affinity of the transcriptional activator Sp1, resulting in higher levels of MDM2 RNA and protein and the subsequent attenuation of the p53 pathway. In humans, SNP309 is shown to associate with accelerated tumor formation in both hereditary and sporadic cancers. A model is proposed whereby SNP309 serves as a rate-limiting event in carcinogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 365 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Canada | 2 | <1% |
| India | 1 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 353 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 73 | 20% |
| Researcher | 68 | 19% |
| Student > Master | 47 | 13% |
| Student > Bachelor | 40 | 11% |
| Professor > Associate Professor | 22 | 6% |
| Other | 67 | 18% |
| Unknown | 48 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 136 | 37% |
| Biochemistry, Genetics and Molecular Biology | 83 | 23% |
| Medicine and Dentistry | 43 | 12% |
| Chemistry | 10 | 3% |
| Computer Science | 9 | 2% |
| Other | 24 | 7% |
| Unknown | 60 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2009.
All research outputs
#7,634,351
of 26,017,215 outputs
Outputs from Cell
#12,206
of 17,318 outputs
Outputs of similar age
#23,227
of 77,591 outputs
Outputs of similar age from Cell
#46
of 79 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 17,318 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 77,591 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.