| Title |
A novel vaginal drug delivery system: anti-HIV bioadhesive film containing abacavir
|
|---|---|
| Published in |
Journal of Materials Science: Materials in Medicine, April 2014
|
| DOI | 10.1007/s10856-014-5204-6 |
| Pubmed ID | |
| Authors |
Kajal Ghosal, Alok Ranjan, Benoy Brata Bhowmik |
| Abstract |
Women are very much susceptible for acquired immunodeficiency syndrome (AIDS) and other sexually transmitted diseases (STDs), mainly due to unprotected heterosexual vaginal intercourse and for some other social and economical disadvantages. Our aim was to formulate and optimize vaginal film of abacavir, a potent nucleoside reverse transcriptase inhibitor, for the treatment of AIDS and HIV. Abacavir films were prepared by solvent evaporation method using sodium alginate (Na-alginate) as the main polymer, Hydroxypropyl Methylcellulose E 15 (HPMC E 15) as the copolymer and glycerol as a humectant. Abacavir sulphate (ABC) was used here as a drug. Films were optimized for various physicochemical parameters such as tensile strength, % elongation at break, swelling capacity, drug content (mg/cm(2)), thickness, folding endurance, bioadhesion, pH, moisture content and SEM. Drug polymer interaction was studied by FTIR Spectra. The drug release study was accomplished in dissolution apparatus. In vivo study was also carried out. This newly formed film was one kind of sustain release type and can be considered as a novel drug carrier system for the treatment of AIDS and other STDs. It was suitable for local as well as systemic effect. The films showed good physicochemical property with good aesthetic appeal. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 25% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Bachelor | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Lecturer | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 18 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 20 | 38% |
| Medicine and Dentistry | 5 | 9% |
| Chemistry | 4 | 8% |
| Materials Science | 3 | 6% |
| Agricultural and Biological Sciences | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 18 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2014.
All research outputs
#18,370,767
of 22,753,345 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#1,185
of 1,400 outputs
Outputs of similar age
#163,662
of 226,135 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#9
of 14 outputs
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