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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of the β Common (βc) Family of Cytokines in Health and Disease
|
|---|---|
| Published in |
Cold Spring Harbor Perspectives in Biology, July 2017
|
| DOI | 10.1101/cshperspect.a028514 |
| Pubmed ID | |
| Authors |
Timothy R. Hercus, Winnie L. T. Kan, Sophie E. Broughton, Denis Tvorogov, Hayley S. Ramshaw, Jarrod J. Sandow, Tracy L. Nero, Urmi Dhagat, Emma J. Thompson, Karen S. Cheung Tung Shing, Duncan R. McKenzie, Nicholas J. Wilson, Catherine M. Owczarek, Gino Vairo, Andrew D. Nash, Vinay Tergaonkar, Timothy Hughes, Paul G. Ekert, Michael S. Samuel, Claudine S. Bonder, Michele A. Grimbaldeston, Michael W. Parker, Angel F. Lopez |
| Abstract |
The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the βc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the βc cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Australia | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 18% |
| Student > Doctoral Student | 5 | 13% |
| Student > Bachelor | 3 | 8% |
| Other | 2 | 5% |
| Student > Ph. D. Student | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 16 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 23% |
| Agricultural and Biological Sciences | 6 | 15% |
| Medicine and Dentistry | 4 | 10% |
| Unspecified | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 14 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2023.
All research outputs
#2,398,900
of 24,088,850 outputs
Outputs from Cold Spring Harbor Perspectives in Biology
#201
of 1,093 outputs
Outputs of similar age
#41,810
of 286,590 outputs
Outputs of similar age from Cold Spring Harbor Perspectives in Biology
#5
of 31 outputs
Altmetric has tracked 24,088,850 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,093 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,590 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.