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Intraneuronal accumulation of Aβ42 induces age-dependent slowing of neuronal transmission in Drosophila

Overview of attention for article published in Neuroscience Bulletin, April 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

patent
2 patents

Citations

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13 Dimensions

Readers on

mendeley
21 Mendeley
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Title
Intraneuronal accumulation of Aβ42 induces age-dependent slowing of neuronal transmission in Drosophila
Published in
Neuroscience Bulletin, April 2014
DOI 10.1007/s12264-013-1409-9
Pubmed ID
Authors

Jing-Ya Lin, Wen-An Wang, Xiao Zhang, Hai-Yan Liu, Xiao-Liang Zhao, Fu-De Huang

Abstract

Beta amyloid (Aβ42)-induced dysfunction and loss of synapses are believed to be major underlying mechanisms for the progressive loss of learning and memory abilities in Alzheimer's disease (AD). The vast majority of investigations on AD-related synaptic impairment focus on synaptic plasticity, especially the decline of long-term potentiation of synaptic transmission caused by extracellular Aβ42. Changes in other aspects of synaptic and neuronal functions are less studied or undiscovered. Here, we report that intraneuronal accumulation of Aβ42 induced an age-dependent slowing of neuronal transmission along pathways involving multiple synapses.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 33%
Student > Ph. D. Student 5 24%
Other 2 10%
Professor 1 5%
Student > Doctoral Student 1 5%
Other 2 10%
Unknown 3 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 43%
Neuroscience 5 24%
Biochemistry, Genetics and Molecular Biology 1 5%
Medicine and Dentistry 1 5%
Computer Science 1 5%
Other 0 0%
Unknown 4 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2022.
All research outputs
#4,904,224
of 23,577,654 outputs
Outputs from Neuroscience Bulletin
#190
of 815 outputs
Outputs of similar age
#47,781
of 228,112 outputs
Outputs of similar age from Neuroscience Bulletin
#3
of 15 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 815 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,112 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.