| Title |
Nuclear receptors and metabolism: from feast to famine
|
|---|---|
| Published in |
Diabetologia, March 2014
|
| DOI | 10.1007/s00125-014-3209-9 |
| Pubmed ID | |
| Authors |
Suk-Hyun Hong, Maryam Ahmadian, Ruth T. Yu, Annette R. Atkins, Michael Downes, Ronald M. Evans |
| Abstract |
The ability to adapt to cycles of feast and famine is critical for survival. Communication between multiple metabolic organs must be integrated to properly metabolise nutrients. By controlling networks of genes in major metabolic organs, nuclear hormone receptors (NHRs) play central roles in regulating metabolism in a tissue-specific manner. NHRs also establish daily rhythmicity by controlling the expression of core clock genes both centrally and peripherally. Recent findings show that many of the metabolic effects of NHRs are mediated through certain members of the fibroblast growth factor (FGF) family. This review focuses on the roles of NHRs in critical metabolic organs, including adipose tissue, liver and muscle, during the fed and fasted states, as well as their roles in circadian metabolism and downstream regulation of FGFs. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Germany | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Japan | 1 | 1% |
| Israel | 1 | 1% |
| Mexico | 1 | 1% |
| Unknown | 66 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 27% |
| Researcher | 9 | 13% |
| Student > Master | 9 | 13% |
| Student > Bachelor | 8 | 11% |
| Professor | 5 | 7% |
| Other | 10 | 14% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 37% |
| Medicine and Dentistry | 19 | 27% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Chemistry | 2 | 3% |
| Nursing and Health Professions | 1 | 1% |
| Other | 5 | 7% |
| Unknown | 11 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2015.
All research outputs
#14,194,875
of 22,753,345 outputs
Outputs from Diabetologia
#4,312
of 5,032 outputs
Outputs of similar age
#117,835
of 221,234 outputs
Outputs of similar age from Diabetologia
#39
of 56 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
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