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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
|
|---|---|
| Published in |
Antiviral Research, February 2014
|
| DOI | 10.1016/j.antiviral.2014.02.014 |
| Pubmed ID | |
| Authors |
Lisa Oestereich, Anja Lüdtke, Stephanie Wurr, Toni Rieger, César Muñoz-Fontela, Stephan Günther |
| Abstract |
Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is available for use in humans. Here, we evaluated the efficacy of the pyrazinecarboxamide derivative T-705 (favipiravir) against Zaire Ebola virus (EBOV) in vitro and in vivo. T-705 suppressed replication of Zaire EBOV in cell culture by 4log units with an IC90 of 110μM. Mice lacking the type I interferon receptor (IFNAR(-)(/)(-)) were used as in vivo model for Zaire EBOV-induced disease. Initiation of T-705 administration at day 6 post infection induced rapid virus clearance, reduced biochemical parameters of disease severity, and prevented a lethal outcome in 100% of the animals. The findings suggest that T-705 is a candidate for treatment of Ebola hemorrhagic fever. |
X Demographics
The data shown below were collected from the profiles of 69 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 14% |
| Japan | 7 | 10% |
| Spain | 2 | 3% |
| Mexico | 1 | 1% |
| Korea, Democratic People's Republic of | 1 | 1% |
| China | 1 | 1% |
| Congo, The Democratic Republic of the | 1 | 1% |
| Australia | 1 | 1% |
| Austria | 1 | 1% |
| Other | 6 | 9% |
| Unknown | 38 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 60 | 87% |
| Scientists | 4 | 6% |
| Science communicators (journalists, bloggers, editors) | 3 | 4% |
| Practitioners (doctors, other healthcare professionals) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 510 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Japan | 4 | <1% |
| Canada | 3 | <1% |
| Indonesia | 2 | <1% |
| United Kingdom | 2 | <1% |
| France | 1 | <1% |
| South Africa | 1 | <1% |
| Vietnam | 1 | <1% |
| Germany | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 487 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 95 | 19% |
| Researcher | 89 | 17% |
| Student > Ph. D. Student | 69 | 14% |
| Student > Master | 66 | 13% |
| Other | 27 | 5% |
| Other | 91 | 18% |
| Unknown | 73 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 127 | 25% |
| Medicine and Dentistry | 93 | 18% |
| Biochemistry, Genetics and Molecular Biology | 48 | 9% |
| Chemistry | 38 | 7% |
| Immunology and Microbiology | 29 | 6% |
| Other | 83 | 16% |
| Unknown | 92 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 280. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2023.
All research outputs
#129,191
of 25,712,965 outputs
Outputs from Antiviral Research
#15
of 2,864 outputs
Outputs of similar age
#995
of 235,793 outputs
Outputs of similar age from Antiviral Research
#1
of 36 outputs
Altmetric has tracked 25,712,965 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,864 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,793 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.