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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor
|
|---|---|
| Published in |
Science, April 2014
|
| DOI | 10.1126/science.1247357 |
| Pubmed ID | |
| Authors |
Simon J. Williams, Kee Hoon Sohn, Li Wan, Maud Bernoux, Panagiotis F. Sarris, Cecile Segonzac, Thomas Ve, Yan Ma, Simon B. Saucet, Daniel J. Ericsson, Lachlan W. Casey, Thierry Lonhienne, Donald J. Winzor, Xiaoxiao Zhang, Anne Coerdt, Jane E. Parker, Peter N. Dodds, Bostjan Kobe, Jonathan D. G. Jones |
| Abstract |
Cytoplasmic plant immune receptors recognize specific pathogen effector proteins and initiate effector-triggered immunity. In Arabidopsis, the immune receptors RPS4 and RRS1 are both required to activate defense to three different pathogens. We show that RPS4 and RRS1 physically associate. Crystal structures of the N-terminal Toll-interleukin-1 receptor/resistance (TIR) domains of RPS4 and RRS1, individually and as a heterodimeric complex (respectively at 2.05, 1.75, and 2.65 angstrom resolution), reveal a conserved TIR/TIR interaction interface. We show that TIR domain heterodimerization is required to form a functional RRS1/RPS4 effector recognition complex. The RPS4 TIR domain activates effector-independent defense, which is inhibited by the RRS1 TIR domain through the heterodimerization interface. Thus, RPS4 and RRS1 function as a receptor complex in which the two components play distinct roles in recognition and signaling. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 24% |
| Germany | 3 | 12% |
| Austria | 1 | 4% |
| United States | 1 | 4% |
| Australia | 1 | 4% |
| France | 1 | 4% |
| Japan | 1 | 4% |
| Netherlands | 1 | 4% |
| Spain | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 8 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 56% |
| Scientists | 10 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 325 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 5 | 2% |
| United States | 2 | <1% |
| France | 1 | <1% |
| Belgium | 1 | <1% |
| Paraguay | 1 | <1% |
| Greece | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 313 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 75 | 23% |
| Researcher | 55 | 17% |
| Student > Master | 50 | 15% |
| Student > Bachelor | 24 | 7% |
| Student > Doctoral Student | 15 | 5% |
| Other | 52 | 16% |
| Unknown | 54 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 180 | 55% |
| Biochemistry, Genetics and Molecular Biology | 66 | 20% |
| Chemistry | 4 | 1% |
| Environmental Science | 4 | 1% |
| Immunology and Microbiology | 3 | <1% |
| Other | 7 | 2% |
| Unknown | 61 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2016.
All research outputs
#1,327,449
of 25,837,817 outputs
Outputs from Science
#22,354
of 83,358 outputs
Outputs of similar age
#12,645
of 242,875 outputs
Outputs of similar age from Science
#250
of 866 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,358 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.9. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,875 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 866 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.