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Evolution of Puma Lentivirus in Bobcats (Lynx rufus) and Mountain Lions (Puma concolor) in North America

Overview of attention for article published in Journal of Virology, April 2014
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Title
Evolution of Puma Lentivirus in Bobcats (Lynx rufus) and Mountain Lions (Puma concolor) in North America
Published in
Journal of Virology, April 2014
DOI 10.1128/jvi.00473-14
Pubmed ID
Authors

Justin S. Lee, Sarah N. Bevins, Laurel E. K. Serieys, Winston Vickers, Ken A. Logan, Mat Aldredge, Erin E. Boydston, Lisa M. Lyren, Roy McBride, Melody Roelke-Parker, Jill Pecon-Slattery, Jennifer L. Troyer, Seth P. Riley, Walter M. Boyce, Kevin R. Crooks, Sue VandeWoude

Abstract

Mountain lions (Puma concolor) throughout North and South America are infected with puma lentivirus B (PLVB). A second, highly divergent lentiviral clade, PLVA, infects mountain lions in southern California and Florida. Bobcats in these two geographic regions are also infected with PLVA, and to date, this is the only strain of lentivirus identified in bobcats. We sequenced full-length PLV genomes in order to characterize the molecular evolution of PLV in bobcats and mountain lions. Low sequence homology (88% average pairwise identity) and frequent recombination (one recombination break point per three isolates analyzed) were observed in both clades. Viral proteins have markedly different patterns of evolution; sequence homology and negative selection were highest in Gag and Pol, and lowest in Vif and Env. 1.7% of sites across the PLV genome evolve under positive selection, indicating host-imposed selection pressure is an important force shaping PLV evolution. PLVA viruses are highly spatially structured reflecting the population dynamics of their primary host - the bobcat. In contrast, the phylogeography of PLVB reflects the highly mobile mountain lion, with diverse PLVB isolates co-circulating in some areas and genetically related viruses present in populations separated by thousands of kilometers. We conclude that PLVA and PLVB are two different viral species with distinct feline hosts and evolutionary histories.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Chile 1 2%
Unknown 50 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Ph. D. Student 7 13%
Student > Master 7 13%
Student > Bachelor 6 12%
Professor > Associate Professor 4 8%
Other 6 12%
Unknown 12 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 38%
Environmental Science 6 12%
Veterinary Science and Veterinary Medicine 5 10%
Biochemistry, Genetics and Molecular Biology 3 6%
Medicine and Dentistry 2 4%
Other 2 4%
Unknown 14 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2014.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Journal of Virology
#23,561
of 25,689 outputs
Outputs of similar age
#165,011
of 224,351 outputs
Outputs of similar age from Journal of Virology
#159
of 198 outputs
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