| Title |
Impact of incident diabetes on atherosclerotic cardiovascular disease according to statin use history among postmenopausal women
|
|---|---|
| Published in |
European Journal of Epidemiology, May 2016
|
| DOI | 10.1007/s10654-016-0153-7 |
| Pubmed ID | |
| Authors |
Yunsheng Ma, Gioia M. Persuitte, Christopher Andrews, Kathleen M. Hovey, Michael J. LaMonte, Annie L. Culver, JoAnn E. Manson, Lawrence S. Phillips, Simin Liu, Charles Eaton, Lisa W. Martin, Barbara V. Howard, Raji Balasubramanian, Chloe E. Bird, Ira S. Ockene, Susan R. Sturgeon, Judith K. Ockene, Lesley Tinker, Rami Nassir, Jacques Rossouw |
| Abstract |
To compare impact of incident diabetes on atherosclerotic cardiovascular disease (ASCVD) risk among postmenopausal women according to statin use. Prospective data from 120,499 postmenopausal women without prevalent diabetes or cardiovascular disease at baseline from the Women's Health Initiative were used. Incident diabetes was self-reported annually and defined as treatment with pills or injectable medication for diabetes. Current statin use was determined at enrollment and years 1, 3, 6, 9 and 13.5 in the three clinical trial arms, and at baseline, year 3, and 13.5 for the observational study. The primary outcome was incident ASCVD events, self-reported annually and adjudicated by blinded local and central physicians. Incident diabetes and statin use status were fitted as time-varying covariates in Cox regression models to assess ASCVD risk during an average follow-up of 13.6 years. For those not on statins at the time of diabetes diagnosis, there was a 42 % increased risk of ASCVD [hazard ratio (HR) 1.42, 95 % CI 1.28-1.58] among women with incident diabetes versus those without diabetes. Among women on statins, there was a 39 % increased risk of ASCVD (HR 1.39, 95 % CI 1.12-1.74) in women with incident diabetes versus those without diabetes. The increased ASCVD risk due to diabetes was similar between women before or after initiating statins (P = 0.89). Whether diabetes was diagnosed before or after statin use did not alter the increased risk of ASCVD associated with diabetes. Mitigating the increased incidence of diabetes in statin users could increase the ASCVD benefit-to-risk ratio of statins. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 29% |
| South Africa | 2 | 10% |
| Sweden | 1 | 5% |
| Ireland | 1 | 5% |
| Spain | 1 | 5% |
| Saudi Arabia | 1 | 5% |
| Netherlands | 1 | 5% |
| Unknown | 8 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 67% |
| Practitioners (doctors, other healthcare professionals) | 4 | 19% |
| Scientists | 3 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 3% |
| Unknown | 33 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 18% |
| Student > Bachelor | 3 | 9% |
| Student > Master | 3 | 9% |
| Student > Ph. D. Student | 3 | 9% |
| Other | 2 | 6% |
| Other | 4 | 12% |
| Unknown | 13 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 29% |
| Nursing and Health Professions | 3 | 9% |
| Engineering | 2 | 6% |
| Psychology | 1 | 3% |
| Environmental Science | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 15 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2017.
All research outputs
#1,382,683
of 24,661,808 outputs
Outputs from European Journal of Epidemiology
#206
of 1,768 outputs
Outputs of similar age
#24,714
of 333,539 outputs
Outputs of similar age from European Journal of Epidemiology
#6
of 23 outputs
Altmetric has tracked 24,661,808 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,768 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,539 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.