Title |
Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability
|
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Published in |
DNA Repair, April 2014
|
DOI | 10.1016/j.dnarep.2014.03.017 |
Pubmed ID | |
Authors |
Guliang Wang, Karen M. Vasquez |
Abstract |
Repetitive genomic sequences can adopt a number of alternative DNA structures that differ from the canonical B-form duplex (i.e. non-B DNA). These non-B DNA-forming sequences have been shown to have many important biological functions related to DNA metabolic processes; for example, they may have regulatory roles in DNA transcription and replication. In addition to these regulatory functions, non-B DNA can stimulate genetic instability in the presence or absence of DNA damage, via replication-dependent and/or replication-independent pathways. This review focuses on the interactions of non-B DNA conformations with DNA repair proteins and how these interactions impact genetic instability. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Canada | 1 | <1% |
Unknown | 159 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 48 | 30% |
Student > Bachelor | 21 | 13% |
Researcher | 18 | 11% |
Student > Master | 16 | 10% |
Student > Doctoral Student | 10 | 6% |
Other | 24 | 15% |
Unknown | 24 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 62 | 39% |
Agricultural and Biological Sciences | 37 | 23% |
Chemistry | 22 | 14% |
Medicine and Dentistry | 5 | 3% |
Unspecified | 2 | 1% |
Other | 8 | 5% |
Unknown | 25 | 16% |