Title |
How common are long-lasting, intensely itching vaccination granulomas and contact allergy to aluminium induced by currently used pediatric vaccines? A prospective cohort study
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Published in |
European Journal of Pediatrics, April 2014
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DOI | 10.1007/s00431-014-2318-2 |
Pubmed ID | |
Authors |
Elisabet Bergfors, Göran Hermansson, Ulla Nyström Kronander, Lars Falk, Lars Valter, Birger Trollfors |
Abstract |
The frequency of long-lasting, intensely itching subcutaneous nodules at the injection site for aluminium (Al)-adsorbed vaccines (vaccination granulomas) was investigated in a prospective cohort study comprising 4,758 children who received either a diphtheria-tetanus-pertussis-polio-Haemophilus influenzae type b vaccine (Infanrix®, Pentavac®) alone or concomitant with a pneumococcal conjugate (Prevenar). Both vaccines were adsorbed to an Al adjuvant. Altogether 38 children (0.83 %) with itching granulomas were identified, epicutaneously tested for Al sensitisation and followed yearly. Contact allergy to Al was verified in 85 %. The median duration of symptoms was 22 months in those hitherto recovered. The frequency of granulomas induced by Infanrix® was >0.66 % and by Prevenar >0.35 %. The risk for granulomas increased from 0.63 to 1.18 % when a second Al-adsorbed vaccine was added to the schedule. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
France | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 76 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 14% |
Other | 10 | 13% |
Student > Ph. D. Student | 9 | 12% |
Student > Master | 9 | 12% |
Student > Doctoral Student | 5 | 6% |
Other | 13 | 17% |
Unknown | 20 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 40% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 10% |
Agricultural and Biological Sciences | 4 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Nursing and Health Professions | 2 | 3% |
Other | 6 | 8% |
Unknown | 24 | 31% |