| Title |
Mutual regulation between Hippo signaling and actin cytoskeleton
|
|---|---|
| Published in |
Protein & Cell, November 2013
|
| DOI | 10.1007/s13238-013-3084-z |
| Pubmed ID | |
| Authors |
Yurika Matsui, Zhi-Chun Lai |
| Abstract |
Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation, apoptosis, and differentiation. How Hippo signaling is regulated has been under extensive investigation. Over the past three years, an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively regulates actin cytoskeleton organization. This review provides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development, and points out outstanding questions for further investigations. |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Netherlands | 1 | 1% |
| United Kingdom | 1 | 1% |
| Korea, Republic of | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 89 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 22% |
| Student > Master | 16 | 17% |
| Researcher | 12 | 13% |
| Student > Doctoral Student | 7 | 7% |
| Professor > Associate Professor | 7 | 7% |
| Other | 15 | 16% |
| Unknown | 16 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 33% |
| Biochemistry, Genetics and Molecular Biology | 27 | 29% |
| Medicine and Dentistry | 10 | 11% |
| Engineering | 2 | 2% |
| Business, Management and Accounting | 1 | 1% |
| Other | 4 | 4% |
| Unknown | 19 | 20% |