Title |
IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)
|
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Published in |
Endocrine-Related Cancer, June 2006
|
DOI | 10.1677/erc.1.01150 |
Pubmed ID | |
Authors |
S Rinaldi, P H M Peeters, F Berrino, L Dossus, C Biessy, A Olsen, A Tjonneland, K Overvad, F Clavel-Chapelon, M C Boutron-Ruault, B Téhard, G Nagel, J Linseisen, H Boeing, P H Lahmann, A Trichopoulou, D Trichopoulos, M Koliva, D Palli, S Panico, R Tumino, C Sacerdote, C H van Gils, P van Noord, D E Grobbee, H B Bueno-de-Mesquita, C A Gonzalez, A Agudo, M D Chirlaque, A Barricarte, N Larrañaga, J R Quiros, S Bingham, K T Khaw, T Key, N E Allen, A Lukanova, N Slimani, R Saracci, E Riboli, R Kaaks |
Abstract |
Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02-1.86), P = 0.01, and 1.44 (95% CI 1.04-1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60-1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50-1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57-1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19-1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 21% |
Professor > Associate Professor | 8 | 12% |
Student > Ph. D. Student | 7 | 11% |
Student > Master | 7 | 11% |
Student > Bachelor | 4 | 6% |
Other | 12 | 18% |
Unknown | 14 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 30% |
Agricultural and Biological Sciences | 17 | 26% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Neuroscience | 2 | 3% |
Computer Science | 1 | 2% |
Other | 2 | 3% |
Unknown | 18 | 27% |