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Mendeley readers
Attention Score in Context
| Title |
Pituitary Adenoma Predisposition Caused by Germline Mutations in the AIP Gene
|
|---|---|
| Published in |
Science, May 2006
|
| DOI | 10.1126/science.1126100 |
| Pubmed ID | |
| Authors |
Outi Vierimaa, Marianthi Georgitsi, Rainer Lehtonen, Pia Vahteristo, Antti Kokko, Anniina Raitila, Karoliina Tuppurainen, Tapani M. L. Ebeling, Pasi I. Salmela, Ralf Paschke, Sadi Gündogdu, Ernesto De Menis, Markus J. Mäkinen, Virpi Launonen, Auli Karhu, Lauri A. Aaltonen |
| Abstract |
Pituitary adenomas are common in the general population, and understanding their molecular basis is of great interest. Combining chip-based technologies with genealogy data, we identified germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene in individuals with pituitary adenoma predisposition (PAP). AIP acts in cytoplasmic retention of the latent form of the aryl hydrocarbon receptor and also has other functions. In a population-based series from Northern Finland, two AIP mutations account for 16% of all patients diagnosed with pituitary adenomas secreting growth hormone and for 40% of the subset of patients who were diagnosed when they were younger than 35 years of age. Typically, PAP patients do not display a strong family history of pituitary adenoma; thus, AIP is an example of a low-penetrance tumor susceptibility gene. |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Norway | 1 | <1% |
| Germany | 1 | <1% |
| Romania | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 165 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 15% |
| Researcher | 26 | 15% |
| Student > Bachelor | 17 | 10% |
| Student > Master | 16 | 9% |
| Other | 11 | 6% |
| Other | 42 | 25% |
| Unknown | 33 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 69 | 40% |
| Agricultural and Biological Sciences | 21 | 12% |
| Biochemistry, Genetics and Molecular Biology | 19 | 11% |
| Neuroscience | 5 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 13 | 8% |
| Unknown | 41 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2017.
All research outputs
#4,141,241
of 22,649,029 outputs
Outputs from Science
#37,432
of 77,781 outputs
Outputs of similar age
#10,467
of 65,693 outputs
Outputs of similar age from Science
#186
of 353 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 77,781 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 61.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 65,693 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 353 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.