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Mendeley readers
Attention Score in Context
| Title |
The evolution of amidine-based brain penetrant BACE1 inhibitors
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry Letters, March 2014
|
| DOI | 10.1016/j.bmcl.2014.03.025 |
| Pubmed ID | |
| Authors |
Daniel Oehlrich, Hana Prokopcova, Harrie J.M. Gijsen |
| Abstract |
Beta site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors hold great potential as disease modifying anti-Alzheimer's drugs. This digest provides an overview of the amidine containing class of BACE1 inhibitors, of which multiple examples are now progressing through clinical trials. The various structural modifications highlight the struggle to combine potency with the optimal properties for a brain penetrant BACE1 inhibitor, and illustrate the crowded competitive landscape. This overview concludes with a summary of potential issues including substrate and target selectivity and a synopsis of the status of the current and past clinical assets. |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| India | 1 | 1% |
| China | 1 | 1% |
| Russia | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 86 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 27% |
| Student > Ph. D. Student | 15 | 16% |
| Student > Bachelor | 11 | 12% |
| Student > Master | 11 | 12% |
| Student > Doctoral Student | 7 | 8% |
| Other | 11 | 12% |
| Unknown | 11 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 28 | 31% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 18% |
| Agricultural and Biological Sciences | 14 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Neuroscience | 4 | 4% |
| Other | 8 | 9% |
| Unknown | 15 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2020.
All research outputs
#1,544,592
of 25,374,647 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#44
of 13,778 outputs
Outputs of similar age
#15,244
of 237,012 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#1
of 120 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,778 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.