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Mendeley readers
Attention Score in Context
| Title |
Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia
|
|---|---|
| Published in |
Blood, December 2013
|
| DOI | 10.1182/blood-2013-11-538983 |
| Pubmed ID | |
| Authors |
Giada Rotunno, Carmela Mannarelli, Paola Guglielmelli, Annalisa Pacilli, Alessandro Pancrazzi, Lisa Pieri, Tiziana Fanelli, Alberto Bosi, Alessandro M. Vannucchi |
| Abstract |
Mutations in the calreticulin (CALR) gene were recently discovered in patients with essential thrombocythemia (ET) lacking the JAK2V617F and MPLW515 mutations, but no information is available on the clinical correlates. In this series, CALR mutations were found in 15.5% of 576 World Health Organization-defined ET patients, accounting for 48.9% of JAK2 and MPL wild-type (wt) patients. CALR-mutated patients were preferentially male and showed higher platelet count and lower hemoglobin and leukocyte count compared with JAK2- and MPL-mutated patients. Patients carrying the CALR mutation had a lower risk of thrombosis than JAK2- and MPL-mutated patients; of interest, their risk was superimposable to patients who were wt for the above mutations. CALR mutation had no impact on survival or transformation to post-ET myelofibrosis. Genotyping for CALR mutations represents a novel useful tool for establishing a clonal myeloproliferative disorder in JAK2 and MPL wt patients with thrombocytosis and may have prognostic and therapeutic relevance. |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| India | 1 | <1% |
| China | 1 | <1% |
| Unknown | 161 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 19% |
| Researcher | 22 | 13% |
| Other | 19 | 12% |
| Student > Doctoral Student | 11 | 7% |
| Professor > Associate Professor | 10 | 6% |
| Other | 32 | 19% |
| Unknown | 40 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 75 | 45% |
| Biochemistry, Genetics and Molecular Biology | 19 | 12% |
| Agricultural and Biological Sciences | 16 | 10% |
| Immunology and Microbiology | 2 | 1% |
| Veterinary Science and Veterinary Medicine | 2 | 1% |
| Other | 3 | 2% |
| Unknown | 48 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2021.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Blood
#14,241
of 33,239 outputs
Outputs of similar age
#97,276
of 320,887 outputs
Outputs of similar age from Blood
#180
of 535 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 33,239 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,887 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 535 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.