| Title |
Leukemia and brain tumors among children after radiation exposure from CT scans: design and methodological opportunities of the Dutch Pediatric CT Study
|
|---|---|
| Published in |
European Journal of Epidemiology, April 2014
|
| DOI | 10.1007/s10654-014-9900-9 |
| Pubmed ID | |
| Authors |
Johanna M. Meulepas, Cécile M. Ronckers, Anne M. J. B. Smets, Rutger A. J. Nievelstein, Andreas Jahnen, Choonsik Lee, Mariëtte Kieft, Johan S. Laméris, Marcel van Herk, Marcel J. W. Greuter, Cécile R. L. P. N. Jeukens, Marcel van Straten, Otto Visser, Flora E. van Leeuwen, Michael Hauptmann |
| Abstract |
Computed tomography (CT) scans are indispensable in modern medicine; however, the spectacular rise in global use coupled with relatively high doses of ionizing radiation per examination have raised radiation protection concerns. Children are of particular concern because they are more sensitive to radiation-induced cancer compared with adults and have a long lifespan to express harmful effects which may offset clinical benefits of performing a scan. This paper describes the design and methodology of a nationwide study, the Dutch Pediatric CT Study, regarding risk of leukemia and brain tumors in children after radiation exposure from CT scans. It is a retrospective record-linkage cohort study with an expected number of 100,000 children who received at least one electronically archived CT scan covering the calendar period since the introduction of digital archiving until 2012. Information on all archived CT scans of these children will be obtained, including date of examination, scanned body part and radiologist's report, as well as the machine settings required for organ dose estimation. We will obtain cancer incidence by record linkage with external databases. In this article, we describe several approaches to the collection of data on archived CT scans, the estimation of radiation doses and the assessment of confounding. The proposed approaches provide useful strategies for data collection and confounder assessment for general retrospective record-linkage studies, particular those using hospital databases on radiological procedures for the assessment of exposure to ionizing or non-ionizing radiation. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Japan | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | 1% |
| Ghana | 1 | 1% |
| Belgium | 1 | 1% |
| Spain | 1 | 1% |
| Greece | 1 | 1% |
| Luxembourg | 1 | 1% |
| Unknown | 88 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 14% |
| Student > Master | 12 | 13% |
| Student > Ph. D. Student | 9 | 10% |
| Student > Bachelor | 8 | 9% |
| Other | 6 | 6% |
| Other | 16 | 17% |
| Unknown | 30 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 31% |
| Physics and Astronomy | 6 | 6% |
| Agricultural and Biological Sciences | 5 | 5% |
| Psychology | 5 | 5% |
| Nursing and Health Professions | 3 | 3% |
| Other | 13 | 14% |
| Unknown | 33 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2018.
All research outputs
#2,102,564
of 23,340,595 outputs
Outputs from European Journal of Epidemiology
#300
of 1,651 outputs
Outputs of similar age
#22,024
of 228,140 outputs
Outputs of similar age from European Journal of Epidemiology
#10
of 24 outputs
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