Title |
Familial Mortality in the Utah Population Database: Characterizing a Human Aging Phenotype
|
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Published in |
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, August 2007
|
DOI | 10.1093/gerona/62.8.803 |
Pubmed ID | |
Authors |
Elizabeth O'Brien, Richard Kerber, Ken Smith, Geraldine Mineau, Ken Boucher, Diana Lane Reed |
Abstract |
We examine the effects of familial longevity and familial mortality on mortality rates for 10 leading causes of death in a Utah Population Database (UPDB) cohort. Familial excess longevity (FEL) and familial standardized mortality ratios (FSMR) were estimated for 666,921 individuals born from 1830 through 1963, who survived to at least age 40. Cox regression analysis shows that familial death and familial longevity have independent effects on cause-specific mortality rates for 10 leading causes of death. A family history of disease increases one's risk of dying from the same cause, whereas a family history of longevity is protective, except in the case of cancer. Families with greater longevity do not die of causes distinct from other members of the cohort, but they die from the same causes at reduced rates. Individuals from longer lived families have lower mortality from most age-related diseases including heart disease, stroke, and diabetes, but not cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 7% |
Spain | 1 | 4% |
Unknown | 25 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 25% |
Student > Ph. D. Student | 3 | 11% |
Professor > Associate Professor | 3 | 11% |
Student > Bachelor | 2 | 7% |
Student > Doctoral Student | 2 | 7% |
Other | 5 | 18% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 21% |
Social Sciences | 5 | 18% |
Agricultural and Biological Sciences | 5 | 18% |
Psychology | 2 | 7% |
Arts and Humanities | 1 | 4% |
Other | 2 | 7% |
Unknown | 7 | 25% |