| Title |
Developmental and pathological angiogenesis in the central nervous system
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, April 2014
|
| DOI | 10.1007/s00018-014-1625-0 |
| Pubmed ID | |
| Authors |
Mario Vallon, Junlei Chang, Haijing Zhang, Calvin J. Kuo |
| Abstract |
Angiogenesis, the formation of new blood vessels from pre-existing vessels, in the central nervous system (CNS) is seen both as a normal physiological response as well as a pathological step in disease progression. Formation of the blood-brain barrier (BBB) is an essential step in physiological CNS angiogenesis. The BBB is regulated by a neurovascular unit (NVU) consisting of endothelial and perivascular cells as well as vascular astrocytes. The NVU plays a critical role in preventing entry of neurotoxic substances and regulation of blood flow in the CNS. In recent years, research on numerous acquired and hereditary disorders of the CNS has increasingly emphasized the role of angiogenesis in disease pathophysiology. Here, we discuss molecular mechanisms of CNS angiogenesis during embryogenesis as well as various pathological states including brain tumor formation, ischemic stroke, arteriovenous malformations, and neurodegenerative diseases. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 151 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 21% |
| Student > Bachelor | 22 | 15% |
| Researcher | 18 | 12% |
| Student > Master | 15 | 10% |
| Student > Doctoral Student | 9 | 6% |
| Other | 14 | 9% |
| Unknown | 41 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 15% |
| Medicine and Dentistry | 19 | 13% |
| Neuroscience | 19 | 13% |
| Biochemistry, Genetics and Molecular Biology | 16 | 11% |
| Engineering | 7 | 5% |
| Other | 23 | 15% |
| Unknown | 44 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2021.
All research outputs
#7,591,533
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,602
of 4,151 outputs
Outputs of similar age
#72,049
of 228,529 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#15
of 43 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,529 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.