| Title |
Impact of High-Dose Vitamin D3 Supplementation in Patients with Crohn’s Disease in Remission: A Pilot Randomized Double-Blind Controlled Study
|
|---|---|
| Published in |
Digestive Diseases and Sciences, December 2016
|
| DOI | 10.1007/s10620-016-4396-7 |
| Pubmed ID | |
| Authors |
Neeraj Narula, Mohan Cooray, Rebecca Anglin, Zack Muqtadir, Alisha Narula, John K. Marshall |
| Abstract |
To assess the tolerability and efficacy of high-dose vitamin D3 in patients with Crohn's disease (CD). This was a randomized, double-blind placebo-controlled trial of high-dose vitamin D3 at 10,000 IU daily (n = 18) compared to 1000 IU daily (n = 16) for 12 months in patients with CD in remission. The primary outcome was change in serum 25-hydroxy-vitamin D levels. Secondary outcomes included clinical relapse rates and changes in mood scores. High-dose vitamin D3 at 10,000 IU daily significantly improved 25-hydroxy-vitamin D levels from a mean of 73.5 nmol/L [standard deviation (SD) 11.7 nmol/L] to 160.8 nmol/L (SD 43.2 nmol/L) (p = 0.02). On an intention-to-treat basis, the rate of relapse was not significantly different between patients receiving low- and high-dose vitamin D3 (68.8 vs 33.3%, p = 0.0844). In per-protocol analysis, clinical relapse of Crohn's disease was less frequently observed in patients receiving a high dose (0/12 or 0%) compared to those receiving a low dose of 1000 IU daily (3/8 or 37.5%) (p = 0.049). Improvement in anxiety and depression scores and a good safety profile were observed in both groups treated with vitamin D3. Oral supplementation with high-dose vitamin D3 at 10,000 IU daily significantly improved serum 25-hydroxy-vitamin D levels. Rates of clinical relapse were similar between both groups. Larger studies using high-dose vitamin D3 for treatment of inflammatory bowel diseases are warranted. CLINICALTRIALS. NCT02615288. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 111 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 18% |
| Student > Postgraduate | 11 | 10% |
| Student > Bachelor | 11 | 10% |
| Researcher | 10 | 9% |
| Other | 7 | 6% |
| Other | 21 | 19% |
| Unknown | 31 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 29% |
| Nursing and Health Professions | 12 | 11% |
| Biochemistry, Genetics and Molecular Biology | 7 | 6% |
| Agricultural and Biological Sciences | 7 | 6% |
| Psychology | 5 | 5% |
| Other | 13 | 12% |
| Unknown | 35 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2021.
All research outputs
#19,086,045
of 24,302,917 outputs
Outputs from Digestive Diseases and Sciences
#3,442
of 4,498 outputs
Outputs of similar age
#302,495
of 429,166 outputs
Outputs of similar age from Digestive Diseases and Sciences
#33
of 41 outputs
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