| Title |
Modulation of peanut-induced allergic immune responses by oral lactic acid bacteria-based vaccines in mice
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, April 2014
|
| DOI | 10.1007/s00253-014-5678-7 |
| Pubmed ID | |
| Authors |
Chengcheng Ren, Qiuxiang Zhang, Gang Wang, Chunqing Ai, Mengsha Hu, Xiaoming Liu, Fengwei Tian, Jianxin Zhao, Yongquan Chen, Miao Wang, Hao Zhang, Wei Chen |
| Abstract |
Peanut allergy (PNA) has becoming a non-negligible health concern worldwide. Thus far, allergen-specific immunotherapy aimed at inducing mucosal tolerance has widely been regarded as a major management strategy for PNA. The safety profiles and the intrinsic probiotic properties of lactic acid bacteria (LAB) render them attractive delivery vehicles for mucosal vaccines. In the present study, we exploited genetically modified Lactococcus lactis to produce peanut allergen Ara h 2 via different protein-targeting systems and their immunomodulatory potency for allergic immune responses in mice were investigated. By comparison with the strain expressing the cytoplasmic form of Ara h 2 (LL1), the strains expressing the secreted and anchored forms of Ara h 2 (LL2 and LL3) were more potent in redirecting a Th2-polarized to a non-allergic Th1 immune responses. Induction of SIgA and regulatory T cells were also observed at the local levels by orally administration of recombinant L. lactis. Our results indicate that allergen-producing L. lactis strains modulated allergic immune responses and may be developed as promising mucosal vaccines for managing allergic diseases. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 33% |
| Australia | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 42 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 27% |
| Researcher | 10 | 23% |
| Student > Bachelor | 6 | 14% |
| Other | 4 | 9% |
| Student > Master | 3 | 7% |
| Other | 3 | 7% |
| Unknown | 6 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 39% |
| Biochemistry, Genetics and Molecular Biology | 6 | 14% |
| Medicine and Dentistry | 5 | 11% |
| Immunology and Microbiology | 3 | 7% |
| Chemistry | 2 | 5% |
| Other | 5 | 11% |
| Unknown | 6 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2016.
All research outputs
#14,105,592
of 24,119,703 outputs
Outputs from Applied Microbiology and Biotechnology
#5,242
of 8,034 outputs
Outputs of similar age
#112,890
of 230,800 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#56
of 96 outputs
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