| Title |
Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, September 2013
|
| DOI | 10.1007/s00018-013-1468-0 |
| Pubmed ID | |
| Authors |
James H. Crichton, Donncha S. Dunican, Marie MacLennan, Richard R. Meehan, Ian R. Adams |
| Abstract |
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable genetic elements, particularly retrotransposons. There are many different types of retrotransposon in mammalian genomes, and these target different points in germline development to amplify and integrate into new genomic locations. Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. Here, we review recent advances in understanding how retrotransposon activity is suppressed in the mammalian germline, how genes involved in germline genome defence mechanisms are regulated, and the consequences of mutating these genome defence genes for the developing germline. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 174 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 27% |
| Researcher | 34 | 19% |
| Student > Master | 19 | 11% |
| Student > Bachelor | 17 | 9% |
| Professor > Associate Professor | 13 | 7% |
| Other | 29 | 16% |
| Unknown | 18 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 79 | 44% |
| Biochemistry, Genetics and Molecular Biology | 64 | 36% |
| Medicine and Dentistry | 6 | 3% |
| Computer Science | 3 | 2% |
| Engineering | 2 | 1% |
| Other | 4 | 2% |
| Unknown | 21 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2014.
All research outputs
#21,709,675
of 24,226,848 outputs
Outputs from Cellular and Molecular Life Sciences
#5,171
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Outputs of similar age
#183,003
of 206,747 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#25
of 27 outputs
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