Title |
Carbapenem-resistant Acinetobacter baumannii in intensive care unit patients: risk factors for acquisition, infection and their consequences
|
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Published in |
Journal of Hospital Infection, January 2007
|
DOI | 10.1016/j.jhin.2006.11.010 |
Pubmed ID | |
Authors |
E.G. Playford, J.C. Craig, J.R. Iredell |
Abstract |
A retrospective case-control study was performed to assess risk factors and the clinical and economic consequences associated with acquisition of carbapenem-resistant Acinetobacter baumannii (CR-AB) in an intensive care unit (ICU) over a 24-month period. CR-AB was acquired by 64 of 1431 ICU admissions; each was matched with two controls. Risk factors associated with CR-AB acquisition included ICU-wide variables, such as 'colonization pressure' (the prevalence of ICU colonized patients) and ICU antibiotic use over the preceding three months, as well as patient-related variables. Among colonized patients, risk factors for CR-AB infection included transfusion and 'colonization density' (the proportion of body sites colonized with CR-AB). CR-AB infection was independently associated with increased hospital mortality [mortality difference: 20%; 95% confidence interval (CI): 1-40%], prolonged ICU stay (median length of stay difference: 15 days; 95% CI: 9-21 days) and prolonged hospital stay (30 days, 11-38 days) compared with matched controls. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
France | 1 | <1% |
Argentina | 1 | <1% |
Fiji | 1 | <1% |
Unknown | 127 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 18% |
Other | 14 | 11% |
Student > Master | 14 | 11% |
Student > Bachelor | 13 | 10% |
Student > Postgraduate | 13 | 10% |
Other | 27 | 21% |
Unknown | 27 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 51 | 39% |
Agricultural and Biological Sciences | 10 | 8% |
Immunology and Microbiology | 8 | 6% |
Nursing and Health Professions | 6 | 5% |
Biochemistry, Genetics and Molecular Biology | 5 | 4% |
Other | 16 | 12% |
Unknown | 35 | 27% |